A Bernoulli Process Approximation for the Reverse Translation of Protein to DNA/mRNA
نویسندگان
چکیده
In proteomics, to find the genomic localization of a gene, a protein may be interpreted back to its DNA/mRNA using the method of reverse translation. A particular amino acid may be translated into more than one codon as the uncertainties exist in the reverse translation of a protein. In this paper, we propose a Bernoulli process approximation based on the usage of frequency distribution for the reverse translation of an amino acid to its DNA/mRNA. A comparison of our proposed method with the existing conventional procedure that is based on random selection of codon, is also presented. Preliminary results of the proposed process are encouraging and it shows improved accuracy and consistency. [Journal of American Science 2010; 6(9):60-64]. (ISSN: 1545-1003).
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